Are you Depressed ? What is the number one cause of depression? It's complicated, and there are multiple causes of major depression . Factors such as genetic vulnerability, severe life stressors, substances you may take (some medications, drugs and alcohol) and medical conditions can affect the way your brain regulates your moods. What happens in the brain during depression? Cortisol and the amygdala. The influx of cortisol triggered by depression also causes the amygdala to enlarge. This is a part of the brain associated with emotional responses. When it becomes larger and more active, it causes sleep disturbances, changes in activity levels, and changes in other hormones. This has been a hot topic and very common among youngsters like us. But we really should move on from this and should cope up with the situation. This has been very common among students mainly because of their studies and those who are not really doing w...